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Graduate and Postdoctoral Research Symposium 2020 has ended
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Mengxi Shen

Imaging of Polypoidal Choroidal Vasculopathy with Swept Source Optical Coherence Tomography Angiography Before and After Treatment with Vascular Endothelial Growth Inhibitors
Oral Presentation
Postdoctoral Associate in Retina Imaging
Polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration that affects a younger population, is defined by the presence of type 1 macular neovascularization characterized by branching vascular networks (BVNs) with polyp-like dilations. As the disease progresses, these polypoidal lesions are likely to rupture and cause massive macular hemorrhages resulting in severe vision loss. For three decades, indocyanine green angiography (ICGA), an intravenous dye-based imaging technique, has been the gold standard for diagnosing PCV, but swept source optical coherence tomography angiography (SS-OCTA), a non-invasive imaging method that is fast, safe, and easily repeatable, has become the preferred imaging method for these neovascular lesions. We report on the use of SS-OCTA for the diagnosis and management of PCV following treatment vascular endothelial growth factor (VEGF) inhibitors.A retrospective review was performed on patients with PCV imaged using SS-OCTA before and after anti-VEGF treatment. This study had Institutional Review Board approval. SS-OCTA imaging was able to clearly visualize PCV without the use of ICGA, and in five cases, the polypoidal components evolved  into flat BVNs that continued to enlarge underneath the adjacent PED without severe vision loss. Since these morphologic changes are associated with improved prognosis, SS-OCTA should be helpful in identifying those cases where the polyps persist and the eyes are at greater risk for vision loss.

Additional author(s): Qiyu Bo, Minlu Song, Giovanni Gregori, Xiaodong Sun, Fenghua Wang, Philip J. Rosenfeld